1-(THIEN-2-YL)-PIPERIDINE

Base Information

• Chemical Name: 1-(THIEN-2-YL)-PIPERIDINE
• CAS No.: 19983-20-1
• Molecular Formula: C9H13 N S
• Molecular Weight: 167.27
• Hs Code.: 2934999090
• Mol file: 19983-20-1.mol

Synonyms:2-Piperidinothiophene;N-(2-Thienyl)piperidine

Chemical Property of 1-(THIEN-2-YL)-PIPERIDINE

Chemical Property:

• Boiling Point: 265.0±13.0℃ (760 Torr)
• PKA: 5.30±0.20(Predicted)
• Flash Point: 114.1±19.8℃
• PSA: 31.48000
• Density: 1.106±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 2.80340
• Storage Temp.: 2-8°C(protect from light)
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Thiophen-2-yl)piperidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(THIEN-2-YL)-PIPERIDINE

There total 6 articles about 1-(THIEN-2-YL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + 2-bromothiophene (1003-09-4) → 1-(thiophen-2-yl)piperidine (19983-20-1)

Guidance literature:

With copper; caesium carbonate; methyl-alpha-D-glucopyranoside; In water; dimethyl sulfoxide; at 100 ℃; Sealed tube; Green chemistry;

DOI:10.1055/s-0039-1690702

Reference yield: 90.0%

piperidine (110-89-4) + 2-Iodothiophene (3437-95-4,149762-92-5) → 1-(thiophen-2-yl)piperidine (19983-20-1)

Guidance literature:

With D-myo-inositol; copper; caesium carbonate; In water; at 100 ℃;

DOI:10.1016/j.tetlet.2019.06.033

Reference yield: 83.0%

<2>Thienyl-phenyl-zink (46116-42-1) + 1-(2,4-dinitrophenoxy)piperidine (110210-11-2) → 1-(thiophen-2-yl)piperidine (19983-20-1)

Guidance literature:

With nickel(II) chloride hexahydrate; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201900510

upstream raw materials:

piperidine

2-bromothiophene

2-Iodothiophene

2,5-dibromothiophen

Downstream raw materials:

1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)piperidine

Refernces

• 1、 Rathnamalala, Chathuranga S. L.,Pino, Nicholas W.,Herring, Bailey S.,Hooper, Mattea,Gwaltney, Steven R.,Chan, Jefferson,Scott, Colleen N.. "Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging". . p. 7640 - 7644. Retrieved 2021/10/12.
• 2、 Zhou, Qifan,Du, Fangyu,Chen, Yuanguang,Fu, Yang,Chen, Guoliang. "“On Water” promoted N-arylation reactions using Cu (0)/myo-inositol catalytic system". supporting information. p. 1938 - 1941. Retrieved 2019/06/24.