(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester
CAS No.:161878-61-1
Molecular Formula:C₂₅H₃₈N₂O₇
Molecular Weight:478.586
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

There total 2 articles about (S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 161878-61-1
(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70percent aq. perchloric acid / 48 h / Ambient temperature

2: 1.) isobutyl chloroformate, 4-methylmorpholine, / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) from -20 deg to RT

With 4-methyl-morpholine; perchloric acid; isobutyl chloroformate;
DOI:10.1021/jm00046a014

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 75190-94-2
(2S)-2-amino-butanoic acid t-butyl ester

: 161878-61-1
(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) from -20 deg to RT;
DOI:10.1021/jm00046a014

Reference yield:

: 161878-61-1
(S)-2-Benzyloxycarbonylamino-4-((S)-1-tert-butoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

: 161878-75-7
(S)-4-((S)-1-tert-Butoxycarbonyl-propylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / tetrahydrofuran / 4 h / 760 Torr

2: 79 percent / diethyl cyanophosphoridate, Et₃N / dimethylformamide / 2 h / Ambient temperature

With diethyl cyanophosphoridate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00046a014