(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Base Information

Chemical Name:(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine
CAS No.:120447-75-8
Molecular Formula:C₁₉H₃₁NO₃S
Molecular Weight:353.526
Hs Code.:

Synonyms:(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Suppliers and Price of (2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Chemical Property:

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Technology Process of (2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

There total 9 articles about (2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 120447-72-5
6-endo-Methyl-8-exo-<3-(phenylsulfonyl)propyl>-2-endo-propyl-7-oxa-1-azabicyclo<3.2.1>octane

: 120447-75-8
(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Guidance literature:: With zinc; In acetic acid;
DOI:10.1021/ja00191a038

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 120447-75-8
(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) THF, hexane, 0 deg C, 20 min; 2.) -78 deg C -> room temp., 3 h

2: 80 percent / HCl / acetone; H₂O / 3 h / Ambient temperature

3: Na₂SO₄ / benzene / 0 - 10 °C

4: benzene / 10 h / Heating

5: 87 percent / zinc dust / aq. acetic acid

With hydrogenchloride; n-butyllithium; sodium sulfate; zinc; In water; acetic acid; acetone; benzene;
DOI:10.1021/ja00191a038

Reference yield:

: 120447-74-7
(Z)-7-Nonen-4-one

: 120447-75-8
(2RS,3SR,6SR)-2-<3-(Phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / hydroxylamine hydrochloride, sodium acetate / aq. ethanol

2: 92 percent / sodium cyanoborohydride, 50percent methanolic HCl / methanol

3: Na₂SO₄ / benzene / 0 - 10 °C

4: benzene / 10 h / Heating

5: 87 percent / zinc dust / aq. acetic acid

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; sodium cyanoborohydride; sodium sulfate; zinc; In methanol; ethanol; acetic acid; benzene;
DOI:10.1021/ja00191a038