N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline

Base Information

• Chemical Name: N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline
• CAS No.: 224577-21-3
• Molecular Formula: C₅₀H₆₀N₆O₉
• Molecular Weight: 889.061
• Mol file: 224577-21-3.mol

Synonyms:N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline

Chemical Property of N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline

There total 10 articles about N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-{4-[(2-toluidinocarbonyl)amino]phenyl}acetic acid (181517-99-7) + L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-L-proline benzyl ester hydrochloride → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline (224577-21-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1021/jm980673g

Reference yield:

Boc-Val-ONSu (3392-12-9) → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline (224577-21-3)

Guidance literature:

Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 4 M HCl / dioxane / 2 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 4 M HCl / dioxane / 2 h / Ambient temperature

5: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

6: 4 M HCl / dioxane / 2 h / Ambient temperature

7: 85 percent / EDC, HOBt, Et₃N / dimethylformamide / 20 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980673g

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-(α-O-benzylaspartyl)-L-valyl-O-benzyl proline (224577-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / dimethylformamide / 1 h

2: 85 percent / EDC, HOBt, Et₃N / dimethylformamide / 20 h / Ambient temperature

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm980673g

upstream raw materials:

2-{4-[(2-toluidinocarbonyl)amino]phenyl}acetic acid

Boc-Val-ONSu

4-aminophenylacetic acid

1--L-valyl>-L-proline phenylmethyl ester

Downstream raw materials:

N-[[4-[[[(2-methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-L-leucyl-L-aspartyl-L-valyl-L-proline