2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

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Chemical Name:2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one
CAS No.:1224170-98-2
Molecular Formula:C₂₃H₂₄ClN₅O₃
Molecular Weight:453.928
Hs Code.:

Synonyms:2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

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Chemical Property of 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

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Technology Process of 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

There total 9 articles about 2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5050-41-9
N-(2-chloroethyl)-pyrrolidine

: 1224172-14-8
2-(4-chlorophenyl)-5-(4-hydroxy-3-methoxyphenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

: 1224170-98-2
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

Guidance literature:: With caesium carbonate; In acetonitrile; at 78 ℃; for 12h;
DOI:10.1016/j.bmcl.2015.05.008

Reference yield: 61.5%

: 1224172-14-8
2-(4-chlorophenyl)-5-(4-hydroxy-3-methoxyphenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1224170-98-2
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

Guidance literature:: With caesium carbonate; In acetonitrile; at 78 ℃; for 12h;

Reference yield:

: 7368-78-7
4-bromoguaiacol

: 1224170-98-2
2-(4-chlorophenyl)-5-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / acetonitrile / 14 h / 20 - 70 °C

2: N,N`-dimethylethylenediamine; copper(l) iodide; potassium carbonate / toluene / 18 h / 105 °C

3: hydrogenchloride / 1,4-dioxane / 24 h / 38 °C

4: sodium nitrite; sulfuric acid; sodium hydroxide / water; tetrahydrofuran / 0.5 h / 0 °C

5: water; tetrahydrofuran / 12 h / 20 °C

6: phosphorus pentachloride / 1,2-dimethoxyethane / 3.5 h / 0 - 20 °C

7: methyl-phenyl-thioether; trifluoroacetic acid / dichloromethane / 17 h / 20 °C

8: caesium carbonate / acetonitrile / 12 h / 78 °C

With hydrogenchloride; copper(l) iodide; methyl-phenyl-thioether; phosphorus pentachloride; sulfuric acid; potassium carbonate; caesium carbonate; trifluoroacetic acid; sodium hydroxide; N,N`-dimethylethylenediamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2015.05.008