3-Morpholinopropanal

Base Information

• Chemical Name: 3-Morpholinopropanal
• CAS No.: 19851-01-5
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.18
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70455301
• Wikidata: Q82277247
• Mol file: 19851-01-5.mol

Synonyms:3-Morpholinopropanal;19851-01-5;3-morpholin-4-ylpropanal;3-MORPHOLIN-4-YL-PROPIONALDEHYDE;3-(MORPHOLIN-4-YL)PROPANAL;4-Morpholinepropanal;3-morpholinopropan-1-one;3-(N-morpholino)propanal;3-morpholinopropionaldehyde;3-(4-Morpholinyl)propanal;SCHEMBL425926;DTXSID70455301;BNWZAKSMZYYVBQ-UHFFFAOYSA-N;MFCD07786959;AKOS012296598;FT-0725608;EN300-182784;A901331

Chemical Property of 3-Morpholinopropanal

Chemical Property:

• Boiling Point: 129-130 °C(Press: 10 Torr)
• PKA: 6.66±0.10(Predicted)
• PSA: 29.54000
• Density: 1.023±0.06 g/cm3(Predicted)
• LogP: -0.15450
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 99.8

Purity/Quality:

99%min ^*data from raw suppliers

3-Morpholinopropanal 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCC=O

Technology Process of 3-Morpholinopropanal

There total 2 articles about 3-Morpholinopropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-morpholin-4-ylpropan-1-ol (4441-30-9) → 3-morpholinopropanal (19851-01-5)

Guidance literature:

With bis(trimethylsilyl) chromate on montmorillonite K-10; In dichloromethane; at 25 ℃; for 0.166667h;

DOI:10.1007/PL00010142

Reference yield:

morpholine (110-91-8,99108-56-2) + acrolein (107-02-8,25068-14-8) → 3-morpholinopropanal (19851-01-5)

Guidance literature:

With magnesium sulfate; In acetonitrile;

DOI:10.1021/jm500930h

Reference yield:

5-chloro-1-methyl-3-tert-butyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (1033444-05-1) + para-fluorobenzylamine (140-75-0) + 3-morpholinopropanal (19851-01-5) → 3-tert-butyl-5-((4-fluorobenzyl)(3-morpholinopropyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (1160360-60-0)

Guidance literature:

para-fluorobenzylamine; 3-morpholinopropanal; With magnesium sulfate; In tetrahydrofuran; at 20 ℃; for 1.5h;

With sodium tetrahydroborate; In tetrahydrofuran; for 2h;

5-chloro-1-methyl-3-tert-butyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; In tert-butyl alcohol; at 100 ℃; for 24h;

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

morpholine

acrolein

Downstream raw materials:

3-tert-butyl-5-((4-fluorobenzyl)(3-morpholinopropyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Refernces

• 1、 Heravi, Majid M.,Ajami, Dariush,Tabar-Heydar, Kourosh. "Oxidation of alcohols by montmorillonite K-10 supported Bis(trimethylsilyl)chromate". . p. 1305 - 1308. Retrieved 2007/10/03.