(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Base Information

Chemical Name:(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate
CAS No.:1180671-56-0
Molecular Formula:C₁₉H₂₂BrN₃O₂
Molecular Weight:404.307
Hs Code.:

Synonyms:(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Suppliers and Price of (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

There total 13 articles about (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 197142-34-0
(1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

: 1180671-56-0
(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: para-bromophenacyl bromide; (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 16h;

With ammonium acetate; In xylene; at 140 ℃; for 3h; Sealed vessel;

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1180671-56-0
(1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 20 °C

2.1: dmap; triethylamine / dichloromethane / 18.16 h / 24 °C

3.1: lithium triethylborohydride / toluene; tetrahydrofuran / 1.08 h / -50 - -45 °C

3.2: 14.42 h / -50 - 20 °C

3.3: 0.08 h / Cooling with ice/water

4.1: diethylzinc / toluene / 0.25 h / -30 °C

4.2: 19.66 h / -25 - -21 °C

4.3: 0.33 h / -25 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.83 h / 20 °C

6.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 1.25 h

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

7.2: 3 h / 140 °C / Sealed vessel

With dmap; ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; diethylzinc; lithium triethylborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;