2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

Base Information

Chemical Name:2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine
CAS No.:1401112-72-8
Molecular Formula:C₁₈H₂₃F₄NO
Molecular Weight:345.38
Hs Code.:

Synonyms:2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

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Chemical Property of 2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

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Technology Process of 2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

There total 3 articles about 2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1513-65-1
2,6-difluoro pyridine

: 1401112-73-9
C₁₃H₂₁F₃O

: 1401112-72-8
2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; mineral oil; at 60 ℃; Inert atmosphere;
DOI:10.1021/ol3023903

Reference yield:

: 210542-62-4
5-Cyclohexyl-1,1,1-trifluoro-pentan-2-one

: 1401112-72-8
2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: sodium hydride / dimethyl sulfoxide; mineral oil / 60 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol3023903

Reference yield:

: 4441-63-8
4-cyclohexylbutanoic acid

: 1401112-72-8
2-((6-cyclohexyl-3-(trifluoromethyl)hex-1-en-3-yl)oxy)-6-fluoropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 60 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol3023903