[(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine

Base Information

• Chemical Name: [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine
• CAS No.: 943320-63-6
• Molecular Formula: C₁₄H₂₀F₃N₃
• Molecular Weight: 287.328
• Mol file: 943320-63-6.mol

Synonyms:[(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine

Chemical Property of [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine

There total 8 articles about [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl-[(R)-1-(4-nitro-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-amine (943320-62-5) → [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine (943320-63-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 2 - 3h; under 2327.23 Torr;

Reference yield:

C19H28F3N3O2 → [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine (943320-63-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm301188x

Reference yield:

tert-butyl N-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]carbamate (1408000-40-7) → [(R)-1-(4-amino-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-dimethyl-amine (943320-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 50 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm301188x

upstream raw materials:

dimethyl-[(R)-1-(4-nitro-2-trifluoromethyl-benzyl)-pyrrolidin-3-yl]-amine

3-(trifluoromethyl)-4-methylaniline

tert-butyl N-[4-methyl-3-(trifluoromethyl)phenyl]carbamate

tert-butyl N-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]carbamate

Downstream raw materials:

(R)-3-azido-N-(4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide

C₃₀H₃₀F₃N₉O