N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Base Information

Chemical Name:N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide
CAS No.:871731-94-1
Molecular Formula:C₂₈H₃₅Br₂NO₃Si
Molecular Weight:621.484
Hs Code.:

Synonyms:N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Suppliers and Price of N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

There total 18 articles about N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: N-(4,8-dibromo-7-hydroxy-3-methyl-naphthalen-1-yl)-3-methoxy-benzamide

: 13154-24-0
triisopropylsilyl chloride

: 871731-94-1
N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jo051762l

Reference yield:

: 871731-74-7
N-(3-acetyl-7-methoxy-1-naphthalenyl)acetamide

: 871731-94-1
N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 95 percent / 4-(dimethylamino)pyridine / acetonitrile / 0.5 h

2.1: KI; NaOH; I₂ / H₂O; dioxane / 1.33 h / 0 - 60 °C

3.1: benzotriazol-1-yloxytris(dimethylamino)phosphonium PF₆^(1-); triethylamine / tetrahydrofuran / 1 h

3.2: 946 mg / NaBH₄ / tetrahydrofuran / 0.67 h

4.1: 98 percent / H₂ / Pd / ethanol / 2 h / 760 Torr

5.1: 90 percent / BBr₃ / CH₂Cl₂; hexane / 11 h / 0 - 20 °C

6.1: 88 percent / pyridine / tetrahydrofuran / 13 h / 0 - 20 °C

7.1: Br₂ / benzene / 23.5 h

8.1: 91 percent / imidazole / dimethylformamide / 2 h / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; hydrogen; bromine; iodine; boron tribromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; potassium iodide; palladium; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo051762l

Reference yield:

: 871731-77-0
[3-(hydroxymethyl)-7-methoxy-1-naphthalenyl]carbamic acid 1,1-dimethylethyl ester

: 871731-94-1
N-{4,8-dibromo-3-methyl-7-[[tris(1-methylethyl)silyl]oxy]-1-naphthalenyl}-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / Pd / ethanol / 2 h / 760 Torr

2: 90 percent / BBr₃ / CH₂Cl₂; hexane / 11 h / 0 - 20 °C

3: 88 percent / pyridine / tetrahydrofuran / 13 h / 0 - 20 °C

4: Br₂ / benzene / 23.5 h

5: 91 percent / imidazole / dimethylformamide / 2 h / 20 °C

With pyridine; 1H-imidazole; hydrogen; bromine; boron tribromide; palladium; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo051762l