16-Methylpregna-1,4-diene-17,21-diol-3,20-dione

Base Information

• Chemical Name: 16-Methylpregna-1,4-diene-17,21-diol-3,20-dione
• CAS No.: 19784-87-3
• Molecular Formula: C22H30 O4
• Molecular Weight: 358.478
• Mol file: 19784-87-3.mol

Synonyms:Pregna-1,4-diene-3,20-dione,17,21-dihydroxy-16a-methyl- (6CI,7CI,8CI); 17a,21-Dihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione

Chemical Property of 16-Methylpregna-1,4-diene-17,21-diol-3,20-dione

Chemical Property:

• Melting Point: 207-210 °C
• Boiling Point: 530.9±50.0 °C(Predicted)
• PKA: 12.65±0.70(Predicted)
• PSA: 74.60000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 2.83280

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

17α,21-Dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 17α,21-Dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione is a reagent used in the synthesis of dexamethasone.

Technology Process of 16-Methylpregna-1,4-diene-17,21-diol-3,20-dione

There total 3 articles about 16-Methylpregna-1,4-diene-17,21-diol-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 17,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione (19784-87-3)

Guidance literature:

ueber mehrere Stufen;

DOI:10.1021/ja01549a090

Reference yield:

→ 17,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione (19784-87-3)

Guidance literature:

Aus 16α-Methylcortexolon mit Mycobact. (globiform 193) in PAA-Matrix <Δ⁴-3-Keto => Δ^1,4-3-Keto>;

DOI:10.1007/BF00928076

Reference yield:

→ 17α,21-Dihyroxy-16α-methyl-pregna-1,4-dien-3,20-dion (18383-24-9,19784-87-3)

Guidance literature:

16α-Methyl-17α-hydroxy-21-acetoxy-3,20-dioxo-Δ⁴-pregnen, Bzl., 2,3-Dichlor-5,6-dicyan-benzochinon;

Downstream raw materials:

21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregna-1,4-diene-3,20-dione

17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate

21-acetoxy-17-hydroxy-16α-methyl-11α-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione

betamethasone