(3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole

Base Information

• Chemical Name: (3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole
• CAS No.: 1226790-28-8
• Molecular Formula: C₂₆H₂₇BrF₃N₅O₅
• Molecular Weight: 626.43

Synonyms:(3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole

Chemical Property of (3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole

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Technology Process of (3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole

There total 1 articles about (3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-tert-butoxycarbonyl-L-4-trifluoromethylphenylalanine (82317-83-7,114873-07-3) + (S)-(+)-3-amino-6-bromo-2,3-dihydro-7-methyl-5-nitro-1H-pyrrolo[1,2-a]benzimidazole (244152-11-2) → (3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole (1226790-28-8)

Guidance literature:

N-tert-butoxycarbonyl-L-4-trifluoromethylphenylalanine; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃;

(S)-(+)-3-amino-6-bromo-2,3-dihydro-7-methyl-5-nitro-1H-pyrrolo[1,2-a]benzimidazole; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/b920260a

Reference yield:

(3S)-6-bromo-2,3-dihydro-7-methyl-5-nitro-3-[Boc-L-4-trifluoromethylphenylalanyl]-1H-pyrrolo[1,2-a]benzimidazole (1226790-28-8) → C26H30F3N5O3

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In methanol; for 6h; under 2585.81 Torr;

DOI:10.1039/b920260a

upstream raw materials:

N-tert-butoxycarbonyl-L-4-trifluoromethylphenylalanine

(S)-(+)-3-amino-6-bromo-2,3-dihydro-7-methyl-5-nitro-1H-pyrrolo[1,2-a]benzimidazole

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