(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

Base Information

Chemical Name:(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide
CAS No.:112260-64-7
Molecular Formula:C₂₅H₂₈O₂P*I
Molecular Weight:518.374
Hs Code.:

Synonyms:(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

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Chemical Property of (4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

Chemical Property:

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Technology Process of (4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

There total 6 articles about (4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 112260-63-6
(4S,5S)-4-(iodomethyl)-2,2,5-trimethyl-1,3-dioxolane

: 603-35-0
triphenylphosphine

: 112260-64-7
(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

Guidance literature:: In neat (no solvent); at 80 ℃; for 50h;

Reference yield:

: 37031-29-1
(-)-dimethy-2,3-O-isopropylidene-L-tartrate

: 112260-64-7
(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

2: 89 percent / tetrabutylammonium bisulfate, 15 percent aq. NaOH / CH₂Cl₂ / 0.75 h / Ambient temperature

3: 69 percent / NaBH₄ / acetonitrile / 20 h / Heating

4: 80 percent / iodine, triphenylphosphine, imidazole / benzene / 1.5 h / Heating

5: 90 percent / neat (no solvent) / 50 h / 80 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; iodine; tetra(n-butyl)ammonium hydrogensulfate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;

Reference yield:

: 70831-49-1,73711-65-6,58789-44-9
(4S,5S)-4-hydroxymethyl-2,2-dimethyl-5-tosyloxymethyl-1,3-dioxolane

: 112260-64-7
(4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / NaBH₄ / acetonitrile / 20 h / Heating

2: 80 percent / iodine, triphenylphosphine, imidazole / benzene / 1.5 h / Heating

3: 90 percent / neat (no solvent) / 50 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; triphenylphosphine; In acetonitrile; benzene;