tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

Base Information

Chemical Name:tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate
CAS No.:1622093-04-2
Molecular Formula:C₃₃H₃₉BrF₃N₇O₅
Molecular Weight:750.616
Hs Code.:

tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

Synonyms:tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

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Chemical Property of tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

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Technology Process of tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

There total 3 articles about tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198211-38-0
(3-aza-bicyclo[3.1.0]hex-6-yl)-carbamic acid tert-butyl ester

: 1622091-28-4
(R)-4-((4-((4-(3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoic acid

: 1622093-04-2
tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1287220-48-7
tert-butyl 4-((4-((4-hydroxybenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate

: 1622093-04-2
tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With di-isopropyl azodicarboxylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1622091-26-2
(R)-tert-butyl 4-((4-((4-(3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate

: 1622093-04-2
tert-butyl (3-(4-((4-((4-((R)-3-bromo-2-methylpropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;