N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide
CAS No.:1616244-54-2
Molecular Formula:C₃₈H₃₄FN₅O₅
Molecular Weight:659.717
Hs Code.:

Synonyms:N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

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Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

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Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

There total 12 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: C₁₅H₉ClN₂O₂

: 1394166-11-0
3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)aniline

: 1616244-54-2
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2014.05.013

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1616244-54-2
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / acetone / 20 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: nitric acid / toluene / 10 h / 110 °C

4: iron / acetic acid / 2 h / 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / acetonitrile / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol

9: triethylamine / dichloromethane / 10 h / 20 °C

With nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.05.013

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 1616244-54-2
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-3-phenyl-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 4 h / 0 °C

2: nitric acid / toluene / 10 h / 110 °C

3: iron / acetic acid / 2 h / 80 °C

4: acetonitrile / 10 h / 85 °C

5: trichlorophosphate / acetonitrile / 6 h / 85 °C

6: chlorobenzene / 30 h / 140 °C

7: iron; ammonium chloride / ethanol

8: triethylamine / dichloromethane / 10 h / 20 °C

With nitric acid; iron; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.05.013