(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

Base Information

Chemical Name:(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide
CAS No.:1448996-72-2
Molecular Formula:C₂₆H₂₆FN₉O₈
Molecular Weight:611.546
Hs Code.:

Synonyms:(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

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Chemical Property of (R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

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Technology Process of (R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

There total 5 articles about (R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1417179-95-3
(R)-2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethanaminium 2,2,2-trifluoroacetate

: 99-33-2
3,5-dinitrobenoyl chloride

: 1448996-72-2
(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 154590-64-4
(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide

: 1448996-72-2
(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 0 - 20 °C

2.1: dichloromethane / 0 - 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C

5.1: triethylamine / acetonitrile / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 1170353-88-4
tert-butyl 4-(2-fluoro-4-((R)-5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate

: 1448996-72-2
(R)-N-(2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)-3,5-dinitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0 - 20 °C

2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041