Benzoic acid, o-cyano-, hydrazide (6CI,8CI)

Base Information

• Chemical Name: Benzoic acid, o-cyano-, hydrazide (6CI,8CI)
• CAS No.: 19731-00-1
• Molecular Formula: C8H7 N3 O
• Molecular Weight: 161.16
• Hs Code.: 2928000090
• Mol file: 19731-00-1.mol

Synonyms:Benzoicacid, o-cyano-, hydrazide (6CI,8CI)

Chemical Property of Benzoic acid, o-cyano-, hydrazide (6CI,8CI)

Chemical Property:

• PSA: 82.40000
• LogP: 1.43688
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Cyanobenzohydrazide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, o-cyano-, hydrazide (6CI,8CI)

There total 4 articles about Benzoic acid, o-cyano-, hydrazide (6CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-cyanobenzoate (6587-24-2) → o-Cyan-benzoesaeure-hydrazid (19731-00-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 5h; Reflux;

DOI:10.1016/j.bmcl.2013.11.037

Reference yield:

2-cyanobenzoic acid (3839-22-3) → o-Cyan-benzoesaeure-hydrazid (19731-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: triethylamine / dichloromethane / 0 °C

3: hydrazine hydrate / methanol / 5 h / Reflux

With thionyl chloride; hydrazine hydrate; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2013.11.037

Reference yield:

2-Cyanobenzoyl chloride (27611-63-8) → o-Cyan-benzoesaeure-hydrazid (19731-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: hydrazine hydrate / methanol / 5 h / Reflux

With hydrazine hydrate; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2013.11.037

upstream raw materials:

2-cyanobenzoic acid

2-Cyanobenzoyl chloride

methyl 2-cyanobenzoate

Refernces

• 1、 Cemischev,Popov. "On the synthesis of some potential tuberculostatic hydrazides and hydrazones of 2-,3- and 4-pyridyl-acetic acid, o-, m- and p-cyanbenzoic acid and 2-benzimidazolyl-acetic acid". . p. 432 - 434. Retrieved 2007/10/04.