3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide
CAS No.:1335115-04-2
Molecular Formula:C₃₇H₃₈F₆N₄O₃S
Molecular Weight:732.79
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

There total 17 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1335116-52-3
3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 22038-85-3
(R)-(-)-2,2,2-Trifluoro-1-phenylethylamine

: 1335115-04-2
3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1335115-04-2
3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol; water / 3 h / 85 °C

1.2: 0 °C / pH ~ 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: copper(l) iodide / dimethyl sulfoxide / 50 - 120 °C / Inert atmosphere

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

5.1: acetonitrile / 3 h

6.1: potassium hydroxide; water / ethanol / 5 h / Reflux

6.2: pH 5 - 6

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; tetrahydrofuran / 50 °C

With N-Bromosuccinimide; copper(l) iodide; oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1586-30-7
6-bromo-3-methyl-2-(3-trifluoromethyl-phenyl)-quinoline-4-carboxylic acid

: 1335115-04-2
3-(1,4'-bipiperidin-1'-ylmethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: copper(l) iodide / dimethyl sulfoxide / 50 - 120 °C / Inert atmosphere

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

4.1: acetonitrile / 3 h

5.1: potassium hydroxide; water / ethanol / 5 h / Reflux

5.2: pH 5 - 6

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; tetrahydrofuran / 50 °C

With N-Bromosuccinimide; copper(l) iodide; oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;