(1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate
CAS No.:1442523-24-1
Molecular Formula:C₁₉H₁₈Cl₂O₄
Molecular Weight:381.256
Hs Code.:

Synonyms:(1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

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Chemical Property of (1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

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Technology Process of (1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

There total 2 articles about (1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2039-83-0
3,4-dichlorostyrene

: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate

: 1442523-24-1
(1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

: (1R,2S)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

Guidance literature:: With C₈₀H₄₈O₁₆P₄Rh₂; In toluene; at 20 ℃; Reagent/catalyst; Overall yield = 72 %; Overall yield = 3.2 g; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2013.04.075

Reference yield:

: 15964-79-1
methyl (3,4-dimethoxyphenyl)acetate

: 1442523-24-1
(1S,2R)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

: (1R,2S)-methyl 2-(3,4-dichlorophenyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24.33 h / 0 - 20 °C / Inert atmosphere

2: C₈₀H₄₈O₁₆P₄Rh₂ / toluene / 20 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; C₈₀H₄₈O₁₆P₄Rh₂; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; acetonitrile;
DOI:10.1016/j.tet.2013.04.075