(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

Base Information

Chemical Name:(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol
CAS No.:121898-13-3
Molecular Formula:C₁₈H₁₅F₇O₂S
Molecular Weight:428.371
Hs Code.:

Synonyms:(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

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Chemical Property of (1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

Chemical Property:

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Technology Process of (1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

There total 1 articles about (1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115878-96-1,115878-97-2,121898-07-5
(S)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((S)-toluene-4-sulfinyl)-pentan-2-one

: 121960-71-2
(1R,2S)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

: 121898-13-3
(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

Guidance literature:: With ammonium hydroxide; sodium tetrahydroborate; In methanol; at -40 ℃; for 0.0833333h; Yield given. Yields of byproduct given;
DOI:10.1055/s-1988-27764

Reference yield: 96.0%

: 121898-13-3
(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

: 121898-18-8
(1S,2R)-3,3,4,4,5,5,5-heptafluoro-1-phenyl-1-(p-tolylthio)pentan-2-ol

Guidance literature:: With trifluoroacetic anhydride; sodium iodide; In acetone; at -40 ℃; for 0.25h;
DOI:10.1055/s-1988-27764

Reference yield:

: 121898-13-3
(1S,2R)-3,3,4,4,5,5,5-Heptafluoro-1-phenyl-1-((R)-toluene-4-sulfinyl)-pentan-2-ol

: 121898-25-7
(2S)-3,3,4,4,5,5,5-heptafluoro-1-phenylpentan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaI, (CF₃CO)2O / acetone / 0.25 h / -40 °C

2: H₂ / Raney-Ni / ethanol / 0.08 h / Heating

With hydrogen; trifluoroacetic anhydride; sodium iodide; nickel; In ethanol; acetone;
DOI:10.1055/s-1988-27764