(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

Base Information

Chemical Name:(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane
CAS No.:625389-72-2
Molecular Formula:C₂₉H₃₅NO₃Si
Molecular Weight:473.687
Hs Code.:

Synonyms:(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

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Technology Process of (1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

There total 1 articles about (1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

: 625389-72-2
(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

1.2: AlCl₃ / CH₂Cl₂ / 0 - 20 °C

2.1: 5.09 g / imidazole / dimethylformamide / 15 h / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0302206

Reference yield: 80.0%

: 625389-72-2
(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

: 625389-74-4
(1S,2R)-1-(tert-butyldiphenylsilyloxy)methyl-2-formyl-2-phenylcyclopropane

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo0302206

Reference yield:

: 625389-72-2
(1S,2R)-1-(tert-butyldiphenylsiloxy)methyl-2-(N-methoxy-N-methylcarbamoyl)-2-phenylcyclopropane

: tert-butyl-diphenyl-(2-phenyl-cyclopropylmethoxy)-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DIBALH / CH₂Cl₂; hexane / 2 h / -78 °C

2: 86 percent / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / acetone; H₂O / 12 h / 20 °C

3: Bu₃P; t-BuSH / tetrahydrofuran / 20 °C

4: t-BuSH; Et₃B / tetrahydrofuran / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; triethyl borane; tributylphosphine; diisobutylaluminium hydride; 2-methylpropan-2-thiol; In tetrahydrofuran; hexane; dichloromethane; water; acetone; 4: Barton reductive radical decarboxylation;
DOI:10.1021/jo0302206