N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

Base Information

Chemical Name:N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide
CAS No.:374067-93-3
Molecular Formula:C₃₁H₃₆BrN₅O₆S
Molecular Weight:686.627
Hs Code.:

Synonyms:N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

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Chemical Property of N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

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Technology Process of N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

There total 3 articles about N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 32779-36-5
5-Bromo-2-chloropyrimidine

: 374067-92-2
4-tert-butyl-N-(5-(4-diethoxymethyl)phenyl-6-(2-hydroxyethoxy)-4-pyrimidinyl)benzenesulfonamide

: 374067-93-3
N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 2.5h;
DOI:10.1021/jm000538f

Reference yield:

: 169677-48-9
N-(5-bromo-6-(2-hydroxyethoxy)-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

: 374067-93-3
N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / CuBr; 2,6-di-tert-butylcresol; PPh₃ / PdCl₂(PPh₃)2 / dioxane / 8 h / Heating

2: 66 percent / NaH / tetrahydrofuran; N,N-dimethyl-acetamide / 2.5 h / 20 °C

With 2,4-di-t-butyl-3-methyl phenol; sodium hydride; triphenylphosphine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;
DOI:10.1021/jm000538f

Reference yield:

: 4-tributylstannylbenzaldehyde diethyl acetal

: 374067-93-3
N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-diethoxymethyl)phenyl-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / CuBr; 2,6-di-tert-butylcresol; PPh₃ / PdCl₂(PPh₃)2 / dioxane / 8 h / Heating

2: 66 percent / NaH / tetrahydrofuran; N,N-dimethyl-acetamide / 2.5 h / 20 °C

With 2,4-di-t-butyl-3-methyl phenol; sodium hydride; triphenylphosphine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;
DOI:10.1021/jm000538f