2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

Base Information

Chemical Name:2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride
CAS No.:930283-31-1
Molecular Formula:C₂₀H₁₆Cl₃FN₂O₂
Molecular Weight:441.717
Hs Code.:

Synonyms:2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

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Technology Process of 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

There total 6 articles about 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 930283-30-0
2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylic acid

: 930283-31-1
2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 930283-31-1
2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / 0.17 h

2.2: 67 h / 20 °C

3.1: acetic acid; hydrogen bromide / 20 °C / Darkness

4.1: hydrogenchloride; magnesium sulfate / 1,4-dioxane / 2.5 h / Reflux

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 15 h / 20 °C

6.1: water; potassium hydroxide / tetrahydrofuran; ethanol / 3.5 h / 50 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; oxalyl dichloride; ethylmagnesium bromide; water; hydrogen bromide; magnesium sulfate; potassium carbonate; acetic acid; N,N-dimethyl-formamide; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 866598-55-2
N-(4-(benzyloxy)phenyl)-2,4-dichlorobenzamidine

: 930283-31-1
2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran / 0.17 h

1.2: 67 h / 20 °C

2.1: acetic acid; hydrogen bromide / 20 °C / Darkness

3.1: hydrogenchloride; magnesium sulfate / 1,4-dioxane / 2.5 h / Reflux

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 15 h / 20 °C

5.1: water; potassium hydroxide / tetrahydrofuran; ethanol / 3.5 h / 50 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; hydrogen bromide; magnesium sulfate; potassium carbonate; acetic acid; N,N-dimethyl-formamide; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b00861