7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one

Base Information

• Chemical Name: 7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one
• CAS No.: 1391824-65-9
• Molecular Formula: C₁₈H₂₅NO₃
• Molecular Weight: 307.367

Synonyms:7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one

Chemical Property of 7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one

There total 3 articles about 7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-((13)C-trideuteriomethyl)-2,6-dimethylnon-2-ene (1391824-63-7) → 7-((13)C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one (1391824-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 h / 0 - 20 °C

2: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: lithium chloride / 18 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; water; acetone;

DOI:10.1002/jlcr.2916

Reference yield:

7-((13)C-trideuteriomethyl)-4-methylheptanoic acid (1391824-64-8) → 7-((13)C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one (1391824-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: lithium chloride / 18 h / 20 °C / Inert atmosphere

With pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran;

DOI:10.1002/jlcr.2916

Reference yield:

(S)-citronellyl bromide (10340-84-8,4895-14-1,58800-75-2,143615-81-0) → 7-((13)C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one (1391824-65-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / diethyl ether / 1 h / 30 °C / Inert atmosphere

1.2: 0.75 h / 0 - 25 °C / Inert atmosphere

1.3: 16 h / 0 - 20 °C / Inert atmosphere

2.1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 h / 0 - 20 °C

3.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: lithium chloride / 18 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; pivaloyl chloride; magnesium; triethylamine; lithium chloride; In tetrahydrofuran; diethyl ether; water; acetone;

DOI:10.1002/jlcr.2916

upstream raw materials:

9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene

7-(⁽¹³⁾C-trideuteriomethyl)-4-methylheptanoic acid

(S)-citronellyl bromide

Downstream raw materials:

8-(⁽¹³⁾C-trideuteriomethyl)-(3S)-tert-butyl 5-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)octanoate

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