(3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one

Base Information

• Chemical Name: (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one
• CAS No.: 330935-00-7
• Molecular Formula: C₂₃H₃₂F₂O₂
• Molecular Weight: 378.503

Synonyms:(3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one

Chemical Property of (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one

There total 2 articles about (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-ol (330934-99-1) → (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one (330935-00-7)

Guidance literature:

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; In dichloromethane;

DOI:10.1016/S0960-894X(03)00703-0

Reference yield:

(2E,4Z)-5-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hexa-2,4-dienal (330934-98-0) → (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one (330935-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: TPAP; NMO / CH₂Cl₂

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(03)00703-0

Reference yield: 50.0%

ethyl(diethylphosphono)(fluoro)acetate (2356-16-3) + (3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-one (330935-00-7) → (2Z,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-2-fluoro-3-methyl-octa-2,4,6-trienoic acid ethyl ester (609767-75-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(03)00703-0

upstream raw materials:

(3E,5Z)-6-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hepta-3,5-dien-2-ol

(2E,4Z)-5-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-hexa-2,4-dienal

Downstream raw materials:

(2Z,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-2-fluoro-3-methyl-octa-2,4,6-trienoic acid ethyl ester

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