cis-1-cyano-5-carbomethoxy-6-methylcyclohexene

Base Information

• Chemical Name: cis-1-cyano-5-carbomethoxy-6-methylcyclohexene
• CAS No.: 109802-94-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 109802-94-0.mol

Synonyms:cis-1-cyano-5-carbomethoxy-6-methylcyclohexene

Chemical Property of cis-1-cyano-5-carbomethoxy-6-methylcyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of cis-1-cyano-5-carbomethoxy-6-methylcyclohexene

There total 3 articles about cis-1-cyano-5-carbomethoxy-6-methylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

potassium cyanide (151-50-8) + cis-4-carbomethoxy-3-methyl-1-(phenylsulfonyl)cyclohexene (109862-70-6) → cis-1-cyano-5-carbomethoxy-6-methylcyclohexene (109802-94-0)

Guidance literature:

Reference yield:

(E)-2-(phenylsulfonyl)-1,3-pentadiene (102860-19-5) → cis-1-cyano-5-carbomethoxy-6-methylcyclohexene (109802-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / toluene; CH₂Cl₂ / 4 h / Ambient temperature

2: 53 percent / acetic acid / methanol; H₂O / 31 h / 50 °C

With aluminium trichloride; acetic acid; In methanol; dichloromethane; water; toluene;

DOI:10.1021/ja00255a027

Reference yield:

5-(chloromercuri)-4-(phenylsulfonyl)pent-2-ene (102815-50-9) → cis-1-cyano-5-carbomethoxy-6-methylcyclohexene (109802-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH (2 M) / diethyl ether / 0.33 h / Ambient temperature

2: AlCl₃ / toluene; CH₂Cl₂ / 4 h / Ambient temperature

3: 53 percent / acetic acid / methanol; H₂O / 31 h / 50 °C

With sodium hydroxide; aluminium trichloride; acetic acid; In methanol; diethyl ether; dichloromethane; water; toluene;

DOI:10.1021/ja00255a027

upstream raw materials:

potassium cyanide

cis-4-carbomethoxy-3-methyl-1-(phenylsulfonyl)cyclohexene

5-(chloromercuri)-4-(phenylsulfonyl)pent-2-ene

(E)-2-(phenylsulfonyl)-1,3-pentadiene

Refernces