methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

Base Information

Chemical Name:methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride
CAS No.:1355082-41-5
Molecular Formula:C₁₅H₁₀BrFN₂O₂*ClH
Molecular Weight:385.62
Hs Code.:

Synonyms:methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

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Chemical Property of methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

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Technology Process of methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

There total 2 articles about methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 160727-95-7
methyl 3-chloro-3-(4-fluorophenyl)-2-oxopropanoate

: 1355082-41-5
methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

Guidance literature:: In ethanol; at 90 ℃; for 12h; Reflux;
DOI:10.1016/j.bmc.2013.05.067

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1355082-41-5
methyl 5-bromo-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / tetrahydrofuran / 3 h / 0 - 85 °C

2: ethanol / 12 h / 90 °C / Reflux

With sodium methylate; In tetrahydrofuran; ethanol; 1: |Darzens Condensation;
DOI:10.1016/j.bmc.2013.05.067