(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

Base Information

Chemical Name:(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one
CAS No.:1061672-53-4
Molecular Formula:C₂₇H₃₆N₂O₂
Molecular Weight:420.595
Hs Code.:

Synonyms:(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

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Chemical Property of (2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

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Technology Process of (2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

There total 2 articles about (2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 110-89-4
piperidine

: 1061672-51-2
(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)pent-2-enoic acid

: 1061672-53-4
(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 15h; optical yield given as %ee;
DOI:10.1021/ol8017374

Reference yield:

: 877203-93-5
(Z)-1-[1-(tert-butyldimethylsinanyloxy)-1,3-butadienyl]piperidine

: 351436-87-8
C₁₈H₂₁NO

: 1061672-53-4
(2E,5S)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

: 1061672-19-2
(2E,5R)-5-(4-methoxyphenylamino)-5-(4-tert-butylphenyl)-1-(piperidin-1-yl)pent-2-en-1-one

Guidance literature:: With (R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; water; In tert-Amyl alcohol; isopropyl alcohol; tert-butyl alcohol; at -30 ℃; for 216h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol8017374