C₇₂H₁₀₁N₆O₁₅PSi₂

Base Information

Chemical Name:C₇₂H₁₀₁N₆O₁₅PSi₂
CAS No.:370867-60-0
Molecular Formula:C₇₂H₁₀₁N₆O₁₅PSi₂
Molecular Weight:1377.77
Hs Code.:

C<sub>72</sub>H<sub>101</sub>N<sub>6</sub>O<sub>15</sub>PSi<sub>2</sub>

Synonyms:C₇₂H₁₀₁N₆O₁₅PSi₂

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Chemical Property of C₇₂H₁₀₁N₆O₁₅PSi₂

Chemical Property:

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Technology Process of C₇₂H₁₀₁N₆O₁₅PSi₂

There total 46 articles about C₇₂H₁₀₁N₆O₁₅PSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 370867-60-0
C₇₂H₁₀₁N₆O₁₅PSi₂

Guidance literature:: Multi-step reaction with 15 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -10 °C

2.1: 2.86 g / NaBH₄ / tetrahydrofuran; H₂O / 3 h / -10 - 20 °C

3.1: 82 percent / Ag₂O / diethyl ether / 14 h

4.1: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

5.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

6.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

7.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

8.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

9.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

10.1: HCl / dioxane / 1.5 h / 0 °C

11.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

12.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

12.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

13.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

14.1: HCl / dioxane / 2.5 h / 0 - 20 °C

15.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 91229-97-9
(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester

: 370867-60-0
C₇₂H₁₀₁N₆O₁₅PSi₂

Guidance literature:: Multi-step reaction with 13 steps

1.1: 82 percent / Ag₂O / diethyl ether / 14 h

2.1: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

4.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

5.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

6.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

7.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

8.1: HCl / dioxane / 1.5 h / 0 °C

9.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

10.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

10.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

11.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

12.1: HCl / dioxane / 2.5 h / 0 - 20 °C

13.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009

Reference yield:

: 112196-58-4
(S)-methyl-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethyl-silyl)oxy)phenyl)propanoate

: 370867-60-0
C₇₂H₁₀₁N₆O₁₅PSi₂

Guidance literature:: Multi-step reaction with 15 steps

1.1: HCl / ethyl acetate / 1 h

2.1: 72 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 15 h / 4 °C

3.1: 100 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

4.1: HCl / dioxane / 0.5 h

5.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

6.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

7.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

8.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

9.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

10.1: HCl / dioxane / 1.5 h / 0 °C

11.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

12.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

12.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

13.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

14.1: HCl / dioxane / 2.5 h / 0 - 20 °C

15.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.12.009