C₇₂H₁₀₁N₆O₁₅PSi₂

Base Information

• Chemical Name: C₇₂H₁₀₁N₆O₁₅PSi₂
• CAS No.: 370867-60-0
• Molecular Formula: C₇₂H₁₀₁N₆O₁₅PSi₂
• Molecular Weight: 1377.77
• Mol file: 370867-60-0.mol

Synonyms:C₇₂H₁₀₁N₆O₁₅PSi₂

Chemical Property of C₇₂H₁₀₁N₆O₁₅PSi₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₂H₁₀₁N₆O₁₅PSi₂

There total 46 articles about C₇₂H₁₀₁N₆O₁₅PSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Glu-OBn (30924-93-7) → C72H101N6O15PSi2 (370867-60-0)

Guidance literature:

Multi-step reaction with 15 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -10 °C

2.1: 2.86 g / NaBH₄ / tetrahydrofuran; H₂O / 3 h / -10 - 20 °C

3.1: 82 percent / Ag₂O / diethyl ether / 14 h

4.1: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

5.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

6.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

7.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

8.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

9.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

10.1: HCl / dioxane / 1.5 h / 0 °C

11.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

12.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

12.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

13.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

14.1: HCl / dioxane / 2.5 h / 0 - 20 °C

15.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.12.009

Reference yield:

(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester (91229-97-9) → C72H101N6O15PSi2 (370867-60-0)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 82 percent / Ag₂O / diethyl ether / 14 h

2.1: LiOH / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

4.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

5.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

6.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

7.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

8.1: HCl / dioxane / 1.5 h / 0 °C

9.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

10.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

10.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

11.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

12.1: HCl / dioxane / 2.5 h / 0 - 20 °C

13.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.12.009

Reference yield:

(S)-methyl-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethyl-silyl)oxy)phenyl)propanoate (112196-58-4) → C72H101N6O15PSi2 (370867-60-0)

Guidance literature:

Multi-step reaction with 15 steps

1.1: HCl / ethyl acetate / 1 h

2.1: 72 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; triethylamine / CH₂Cl₂ / 15 h / 4 °C

3.1: 100 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

4.1: HCl / dioxane / 0.5 h

5.1: 60 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 19 h / 0 - 20 °C

6.1: LiOH / tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

7.1: 77 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 15 h / 0 - 20 °C

8.1: 75 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

9.1: morpholine / (PPh₃)4Pd / tetrahydrofuran / 2 h

10.1: HCl / dioxane / 1.5 h / 0 °C

11.1: 84 percent / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / CH₂Cl₂ / 17 h / 20 °C

12.1: zinc; acetic acid / tetrahydrofuran / 4.5 h

12.2: 77 percent / triethylamine / tetrahydrofuran / 6 h / 0 - 20 °C

13.1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 3 h / 20 °C / 760 Torr

14.1: HCl / dioxane / 2.5 h / 0 - 20 °C

15.1: 211 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 18 h / 0 - 20 °C

With morpholine; 1H-imidazole; hydrogenchloride; lithium hydroxide; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.12.009

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-isoleucine

Boc-Glu-OBn

Boc-Tyr-OH

H-Phe-O-allyl hydrochloride