(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

Base Information

Chemical Name:(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine
CAS No.:156274-76-9
Molecular Formula:C₁₈H₁₅NO₂S
Molecular Weight:309.389
Hs Code.:

Synonyms:(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

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Chemical Property of (+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

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Technology Process of (+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

There total 5 articles about (+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 156274-75-8
(+/-)-6-chloro-7,10-dioxo-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 156274-76-9
(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

Guidance literature:: With aluminium trichloride; 1.) 0 deg C, 1 h, 2.) 80 deg C, 5 h;
DOI:10.1016/S0223-5234(97)83975-X

Reference yield:

: 131526-66-4
Bis<2-<2-(ethoxycarbonyl)-5-oxo-1-pyrrolidinyl>phenyl> Disulphide

: 156274-76-9
(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaBH₄ / 1.) EtOH, 20 min, 2.) EtOH, room temperature, 15 h

2: 59 percent / Na / toluene; ethanol / 5 h / Heating

3: 90 percent / 6 N HCl / acetic acid / 5 h / Heating

4: 89 percent / SO₂Cl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

5: 51 percent / AlCl₃ / 1.) 0 deg C, 1 h, 2.) 80 deg C, 5 h

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; sulfuryl dichloride; sodium; In ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0223-5234(97)83975-X

Reference yield:

: 156274-74-7
(+/-)-7,10-dioxo-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

: 156274-76-9
(+/-)-7,10-dioxo-6-phenyl-6,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzothiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / SO₂Cl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 51 percent / AlCl₃ / 1.) 0 deg C, 1 h, 2.) 80 deg C, 5 h

With aluminium trichloride; sulfuryl dichloride; In dichloromethane;
DOI:10.1016/S0223-5234(97)83975-X