4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

Base Information

Chemical Name:4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
CAS No.:1312552-03-6
Molecular Formula:C₂₉H₃₇N₃O₂
Molecular Weight:459.632
Hs Code.:

Synonyms:4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

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Chemical Property of 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

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Technology Process of 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

There total 17 articles about 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1312552-02-5
4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide

: 1312552-03-6
4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

Guidance literature:: 4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide; With boron tribromide; In dichloromethane; at 0 ℃; for 1.5h;

With potassium hydroxide; In dichloromethane; water;

Reference yield:

: 1711-05-3
m-anisoyl chloride

: 1312552-03-6
4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C

2.1: potassium permanganate / water; tert-butyl alcohol / 7.5 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

3.2: 14 h / 20 °C

4.1: sodium tetrahydroborate / ethanol; water / 2 h / 20 °C

4.2: pH 5

5.1: hydrogenchloride / chloroform; water / 14 h / 20 °C

6.1: potassium carbonate / acetonitrile / 72 h / Reflux

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 60 °C / 2327.23 Torr

8.1: potassium carbonate / acetone / 14 h / Reflux

9.1: boron tribromide / dichloromethane / 1.5 h / 0 °C

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; hydrogen; boron tribromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane; chloroform; water; acetone; acetonitrile; tert-butyl alcohol;

Reference yield:

: 5259-72-3,10060-40-9,111-78-4
cyclo-octa-1,5-diene

: 1312552-03-6
4-[(10-allyl-9,10-diazatricyclo[4.2.1.1(2,5)]dec-9-yl)-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / dichloromethane / 0 °C

1.2: 16 h / 20 °C

2.1: ytterbium(III) triflate / tetrahydrofuran / 20 h / Reflux

3.1: triethylamine; methanesulfonyl chloride / dmap / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

4.1: sodium azide; ammonium chloride / ethanol; water / 4 h / Reflux

5.1: bromine / cyclohexane; water / 5 h / 20 °C

6.1: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / Reflux

6.2: pH 8

7.1: potassium carbonate / acetonitrile / 72 h / Reflux

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 60 °C / 2327.23 Torr

9.1: potassium carbonate / acetone / 14 h / Reflux

10.1: boron tribromide / dichloromethane / 1.5 h / 0 °C

With sodium azide; hydrogen; bromine; boron tribromide; sodium carbonate; potassium carbonate; ammonium chloride; methanesulfonyl chloride; triethylamine; triphenylphosphine; ytterbium(III) triflate; dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water; acetone; acetonitrile;