(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

Base Information

Chemical Name:(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate
CAS No.:160400-71-5
Molecular Formula:C₄₇H₄₉N₄O₁₃P
Molecular Weight:908.899
Hs Code.:

Synonyms:(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

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Chemical Property of (S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

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Technology Process of (S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

There total 3 articles about (S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 160400-69-1
Sp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate

: 160400-71-5
(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;

Reference yield:

: 133471-17-7,133574-78-4,252897-94-2
5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl H-phosphonate

: 160400-71-5
(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; water; palladium diacetate; triethylamine / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h

With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; In tetrahydrofuran;

Reference yield:

: 591-50-4
iodobenzene

: 160400-71-5
(S)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; water; palladium diacetate; triethylamine / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h

With 1,1'-bis-(diphenylphosphino)ferrocene; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; In tetrahydrofuran;