4-METHYL-2-CHLOROBIPHENYL

Base Information

• Chemical Name: 4-METHYL-2-CHLOROBIPHENYL
• CAS No.: 19493-33-5
• Molecular Formula: C13H11 Cl
• Molecular Weight: 202.683
• Hs Code.: 2903999090
• Mol file: 19493-33-5.mol

Synonyms:Biphenyl,2-chloro-4'-methyl- (7CI,8CI); 2-Chloro-4'-methyl-1,1'-biphenyl

Chemical Property of 4-METHYL-2-CHLOROBIPHENYL

Chemical Property:

• PSA: 0.00000
• LogP: 4.31540

Purity/Quality:

99% ^*data from raw suppliers

4-METHYL-2-CHLOROBIPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-2-CHLOROBIPHENYL

There total 21 articles about 4-METHYL-2-CHLOROBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-1-chlorobenzene (694-80-4) + p-tolylboronic pinacol ester (195062-57-8) → 2-chloro-4'-methyl-1,1'-biphenyl (19493-33-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; In neat (no solvent); at 110 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201300741

Reference yield: 92.0%

2-iodochlorobenzene (615-41-8) + sodium tetrakis(4-tolyl)borate (15738-23-5) → 2-chloro-4'-methyl-1,1'-biphenyl (19493-33-5)

Guidance literature:

With sodium carbonate; palladium dichloride; In methanol; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tet.2010.07.022

Reference yield: 89.0%

2-bromo-1-chlorobenzene (694-80-4) + tributyl(p-tolyl)stannane (31614-66-1) → 2-chloro-4'-methyl-1,1'-biphenyl (19493-33-5)

Guidance literature:

With palladium diacetate; cesium fluoride; tricyclohexylphosphine; In neat (no solvent); at 110 ℃; for 24h; under 760.051 Torr; Sealed tube;

DOI:10.1002/ejoc.201701463

upstream raw materials:

p-methylbenzenediazonium chloride

chlorobenzene

2-iodochlorobenzene

4-methylphenylboronic acid

Downstream raw materials:

4'-Bromomethyl-2-chloro-biphenyl