N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

Base Information

Chemical Name:N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl
CAS No.:694527-96-3
Molecular Formula:C₄₈H₇₉N₅O₁₂
Molecular Weight:918.182
Hs Code.:

Synonyms:N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

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Technology Process of N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

There total 6 articles about N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 308279-71-2
(S)-3-Benzyloxy-2-((2S,3R)-2-{(S)-2-[((2R,3R)-3-hydroxy-2-methyl-nonanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-pentanoylamino)-propionic acid allyl ester

: 656252-98-1
Boc-L-allo-Thr(Me)-Gly-OH

: 694527-96-3
N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: With dmap; camphor-10-sulfonic acid; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 630424-73-6,1396972-31-8
(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-methoxybutanoic acid

: 694527-96-3
N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N; 1-hydroxybenzotriazole; EDCI*HCl / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / ethanol / 20 °C

3: 86 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: (2S,3S)-2-tert-Butoxycarbonylamino-3-methoxy-butyric acid benzyl ester

: 694527-96-3
N-((2R,3R)-3-[Boc-L-allo-Thr(Me)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / methanol / 4 h / 20 °C

2: 98 percent / Et₃N; 1-hydroxybenzotriazole; EDCI*HCl / CH₂Cl₂ / 0 - 20 °C

3: 100 percent / H₂ / Pd/C / ethanol / 20 °C

4: 86 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

With dmap; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2003.10.055