(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Name:(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1604820-65-6
Molecular Formula:C₄₂H₃₉NO₄
Molecular Weight:621.776
Hs Code.:

Synonyms:(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about (E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1604820-88-3
(E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-3-(2-(3,4-dimethoxystyryl)phenyl)-1-p-tolylprop-2-yn-1-amine

: 1604820-65-6
(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 3h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201301806

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1604820-65-6
(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 6 h / 20 °C

4.1: copper(l) iodide / toluene / 3 h / 100 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 5.1: |Heck Reaction;
DOI:10.1002/ejoc.201301806

Reference yield:

: 1604820-73-6
(E)-4-(2-ethynylstyryl)-1,2-dimethoxybenzene

: 1604820-65-6
(E)-2-benzyl-4-(2-(3,4-dimethoxyphenyl)-1H-inden-1-ylidene)-6,7-dimethoxy-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide / toluene / 3 h / 100 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; toluene; 2: |Heck Reaction;
DOI:10.1002/ejoc.201301806