1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone

Base Information

• Chemical Name: 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone
• CAS No.: 117023-19-5
• Molecular Formula: C₂₉H₃₁F₂NO₄
• Molecular Weight: 495.566
• Mol file: 117023-19-5.mol

Synonyms:1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone

Chemical Property of 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone

There total 7 articles about 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

florisil + 4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) + α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol (117022-73-8) → 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone (117023-19-5)

Guidance literature:

With potassium iodide; sodium carbonate; In methanol; dichloromethane; water; acetone; butan-1-ol; benzene;

Reference yield: 34.0%

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) + α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol (117022-73-8) → 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone (117023-19-5)

Guidance literature:

With sodium carbonate; potassium iodide; In butan-1-ol; Heating;

DOI:10.1021/jm00121a022

Reference yield:

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (51535-00-3) → 1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone (117023-19-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, reflux, 15 min; 2) THF, room temperature, overnight

2: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

3: 91 percent / H₂ / 5percent Pd/C / ethanol / 70 °C / 2585.7 Torr

4: 34 percent / Na₂CO₃, KI / butan-1-ol / Heating

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; butan-1-ol;

DOI:10.1021/jm00121a022

upstream raw materials:

4-(3-chloropropoxy)-3-methoxyacetophenone

α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate

1-(3-methoxy-4-hydroxyphenyl)ethanone