(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

Base Information

Chemical Name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester
CAS No.:130799-26-7
Molecular Formula:C₂₁H₂₂N₈O₆
Molecular Weight:482.456
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

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Chemical Property of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

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Technology Process of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

There total 1 articles about (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 95484-99-4
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-6,6-dimethyl-5-oxo-heptanoic acid methyl ester

: 130799-26-7
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 1h;
DOI:10.1021/jm00106a016

Reference yield:

: 130799-26-7
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

: 130799-21-2
3-((S)-4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyrylamino)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) i-BuOCOCl, N-methylmorpholine, CF₃COOH, 2.) 4-(N,N-dimethylamino)pyridine / 1.) DMF, RT, 20 min, 2.) RT, 4 d

2: 0.5 N NaOH / 3 h / Ambient temperature

With 4-methyl-morpholine; dmap; sodium hydroxide; trifluoroacetic acid; isobutyl chloroformate;
DOI:10.1021/jm00106a016

Reference yield:

: 582-33-2
3-aminobenzoic acid ethyl ester

: 130799-26-7
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-methyl ester

: 130799-29-0
3-((S)-4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoic acid ethyl ester

: 130799-28-9
3-((S)-4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoic acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; dmap; trifluoroacetic acid; isobutyl chloroformate; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, RT, 20 min, 2.) RT, 4 d;
DOI:10.1021/jm00106a016