(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

Base Information

Chemical Name:(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone
CAS No.:1355016-41-9
Molecular Formula:C₁₉H₃₀ClN₃O
Molecular Weight:351.92
Hs Code.:

Synonyms:(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

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Chemical Property of (4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

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Technology Process of (4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

There total 6 articles about (4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₈ClN₃O

: 1355016-41-9
(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol; for 6h;
DOI:10.1016/j.bmc.2011.11.005

Reference yield:

: 1329055-06-2
2-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

: 1355016-41-9
(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / 60 °C

2: methanol / 2 h

3: sodium tris(acetoxy)borohydride / methanol / 6 h

With sodium tris(acetoxy)borohydride; hydrazine hydrate; In methanol; ethanol;
DOI:10.1016/j.bmc.2011.11.005

Reference yield:

: 897445-35-1
tert-butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate

: 1355016-41-9
(4-chlorophenyl)(4-(2-(3,3-dimethylbutylamino)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

1.2: Saturated solution

2.1: potassium carbonate / acetonitrile / 24 h / Reflux

3.1: hydrazine hydrate / ethanol / 2 h / 60 °C

4.1: methanol / 2 h

5.1: sodium tris(acetoxy)borohydride / methanol / 6 h

With sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.11.005