(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

Base Information

Chemical Name:(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol
CAS No.:1338384-63-6
Molecular Formula:C₁₈H₂₇NO₅
Molecular Weight:337.416
Hs Code.:

Synonyms:(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

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Technology Process of (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

There total 4 articles about (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1340570-80-0
1-(1'-Boc-2'-pyrrolidinyl)-2-(o-benzyloxy-p-hydroxymethylphenoxy)ethanol

: 1338384-64-7
(1S,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

: 1338384-63-6
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 760.051 Torr;
DOI:10.1021/jm200937t

Reference yield:

: 152665-75-3
(S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1338384-63-6
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / -20 - -10 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm200937t

Reference yield:

: C₁₄H₁₁O₃^(1-)*Na⁽¹⁺⁾

: 1338384-63-6
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o-hydroxy-p-methylphenoxy)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / -20 - -10 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm200937t