8-Chloro-2-methylquinazolin-4(3H)-one

Base Information

• Chemical Name: 8-Chloro-2-methylquinazolin-4(3H)-one
• CAS No.: 19407-54-6
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.6177
• Hs Code.: 2933990090
• Mol file: 19407-54-6.mol

Synonyms:8-Chloro-2-methyl-3H-quinazolin-4-one;

Chemical Property of 8-Chloro-2-methylquinazolin-4(3H)-one

Chemical Property:

• Refractive Index: 1.664
• Boiling Point: 329.8±44.0 °C(Predicted)
• PKA: 0.96±0.20(Predicted)
• PSA: 45.75000
• Density: 1.43 g/cm³
• LogP: 1.88490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Chloro-2-methylquinazolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Chloro-2-methylquinazolin-4(3H)-one

There total 2 articles about 8-Chloro-2-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-amino-3-chlorobenzoic acid (6388-47-2) + acetic anhydride (108-24-7) → 8-chloro-2-methylquinazolin-4(3H)-one (19407-54-6)

Guidance literature:

2-amino-3-chlorobenzoic acid; acetic anhydride; at 20 ℃;

With ammonia; In water; at 20 ℃; for 7h;

DOI:10.1016/j.ejmech.2012.02.001

Reference yield: 41.0%

2-amino-3-chlorobenzoic acid (6388-47-2) + acetonitrile (75-05-8,26809-02-9) → 8-chloro-2-methylquinazolin-4(3H)-one (19407-54-6)

Guidance literature:

With copper(II) oxide; trichlorophosphate; at 0 - 20 ℃; for 16h;

DOI:10.1039/c7cc01406f

Reference yield:

8-chloro-2-methylquinazolin-4(3H)-one (19407-54-6) → C16H11Cl3N2O

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 120 °C / Sealed tube

2: platinum on carbon; hydrogen / ethyl acetate

With platinum on carbon; hydrogen; acetic acid; In ethyl acetate;

upstream raw materials:

2-amino-3-chlorobenzoic acid

acetic anhydride

acetonitrile

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