(2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine

Base Information

• Chemical Name: (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine
• CAS No.: 1380511-85-2
• Molecular Formula: C₄₆H₆₃NO₄Si₂
• Molecular Weight: 750.182

Synonyms:(2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine

Chemical Property of (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine

There total 8 articles about (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S,4R)-1-[(E)-6-[(tert-butyldiphenylsilyl)oxy]-2-methylhex-2-en-1-yl]-2-hydroxymethyl-4-(methoxymethoxy)pyrrolidine (1380511-84-1) + tert-butylchlorodiphenylsilane (58479-61-1) → (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine (1380511-85-2)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201200073

Reference yield:

methyl (2S,4R)-1-[(E)-6-tert-butyldiphenylsilyloxy-2-methylhex-2-enyl]-4-hydroxypyrrolidine-2-carboxylate (1380511-79-4) → (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine (1380511-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 168 h / 0 - 20 °C / Inert atmosphere; Reflux

1.2: 3 h / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1002/ejoc.201200073

Reference yield:

C24H34O4SSi → (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine (1380511-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triethylamine; triphenylphosphine / tetrahydrofuran; acetonitrile / 24 h / 20 °C / Inert atmosphere

2.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 168 h / 0 - 20 °C / Inert atmosphere; Reflux

2.2: 3 h / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

DOI:10.1002/ejoc.201200073

upstream raw materials:

methyl (2S,4R)-1-[(E)-6-tert-butyldiphenylsilyloxy-2-methylhex-2-enyl]-4-hydroxypyrrolidine-2-carboxylate

methyl (2S,4R)-1-[(E)-6-tert-butyldiphenylsilyloxy-2-methylhex-2-enyl]-4-(methoxymethyloxy)-pyrrolidine-2-carboxylate

(2S,4R)-1-[(E)-6-[(tert-butyldiphenylsilyl)oxy]-2-methylhex-2-en-1-yl]-2-hydroxymethyl-4-(methoxymethoxy)pyrrolidine

tert-butylchlorodiphenylsilane

Downstream raw materials:

anti-(2R,3R)-2-[E-2-(2-bromo-5-methoxyphenyl)-ethenyl]-1-[(2S,4R)-2-(tert-butyldiphenylsilyloxymethyl)-4-methoxymethyloxy-pyrrolidin-1-yl]-3-(3-tert-butyldiphenylsilyloxypropyl)-4-methyl-4-pentene-1-one

anti-(2S,3S)-2-[E-2-(2-bromo-5-methoxyphenyl)-ethenyl]-1-[(2S,4R)-2-(tert-butyldiphenylsilyloxymethyl)-4-methoxymethyloxy-pyrrolidin-1-yl]-3-(3-tert-butyldiphenylsilyloxypropyl)-4-methyl-4-pentene-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1380511-85-2 (2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-2-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethyloxy)pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send