4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE

Base Information

• Chemical Name: 4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE
• CAS No.: 19397-74-1
• Molecular Formula: C₁₅H₁₄O₂S
• Molecular Weight: 258.341
• Mol file: 19397-74-1.mol

Synonyms:4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE;4,5-dihydro-2-(ethoxycarbonyl)naphtho[1,2-b]thiophene

Chemical Property of 4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE

Chemical Property:

• Melting Point: 82-83 °C(Solv: ethanol (64-17-5))
• Boiling Point: 417.7±33.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 3.69040
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPHTHO(1,2-B)THIOPHENE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE

There total 8 articles about 4,5-DIHYDRO-2-(ETHOXYCARBONYL)NAPTHO(1,2-B)THIOPENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-chloro-2-formyl-3,4-dihydronaphthalene (3262-03-1) + ethyl 2-sulfanylacetate (623-51-8) → 4,5-dihydronaphthalene[1,2-b]thiophene-2-carboxylic acid ethyl ester (19397-74-1)

Guidance literature:

With 40% KF/Al₂O₃ ; at 20 ℃; for 0.75h; Solvent; Reagent/catalyst;

DOI:10.1055/s-0033-1338299

Reference yield: 66.3%

ethyl laurate (106-33-2) + 1-chloro-2-formyl-3,4-dihydronaphthalene (3262-03-1) → 4,5-dihydronaphthalene[1,2-b]thiophene-2-carboxylic acid ethyl ester (19397-74-1)

Guidance literature:

With sodium ethanolate; In ethanol; at 0 - 20 ℃;

Reference yield: 60.0%

1-chloro-2-formyl-3,4-dihydronaphthalene (3262-03-1) + ethyl 2-sulfanylacetate (623-51-8) → 4,5-dihydronaphthalene[1,2-b]thiophene-2-carboxylic acid ethyl ester (19397-74-1) + ethyl 2-[(2-formyl-3,4-dihydronaphthalen-1-yl)thio]acetate (1447684-28-7)

Guidance literature:

With 40% KF/Al₂O₃ ; In acetonitrile; at 20 ℃; for 0.75h; Solvent; Reagent/catalyst;

DOI:10.1055/s-0033-1338299

upstream raw materials:

1-chloro-2-formyl-3,4-dihydronaphthalene

ethyl 2-sulfanylacetate

3,4-dihydronaphthalene-1(2H)-one

ethyl 2-[(2-formyl-3,4-dihydronaphthalen-1-yl)thio]acetate

Downstream raw materials:

ethyl naphtho<1,2-b>thiophene-2-carboxylate

1,1-dioxonaphtho[1,2-b]thiophen-2-ylmethyl N-p-chlorophenyl carbamate

α-Nsmoc-Phg-OH

α-Nsmoc-Phg-F