N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

Base Information

Chemical Name:N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide
CAS No.:1351089-31-0
Molecular Formula:C₂₀H₂₇N₇O₃S
Molecular Weight:445.545
Hs Code.:

Synonyms:N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

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Technology Process of N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

There total 5 articles about N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 868849-54-1
4-(2-methoxyethyl)piperidine hydrochloride

: 1351087-88-1
4-fluoro-N-methyl-3-(9H-purin-6-ylamino)benzenesulfonamide

: 1351089-31-0
N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 20h; Microwave irradiation; Sealed vessel;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351089-31-0
N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / -35 °C

3: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

4: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

5: triethylamine / 1-methyl-pyrrolidin-2-one / 20 h / 150 °C / Microwave irradiation; Sealed vessel

With chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351089-31-0
N-methyl-4-{4-[2-(methyloxy)ethyl]-1-piperidinyl}-3-(1H-purin-6-ylamino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

3: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

4: triethylamine / 1-methyl-pyrrolidin-2-one / 20 h / 150 °C / Microwave irradiation; Sealed vessel

With hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;