methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

Base Information

Chemical Name:methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate
CAS No.:1609574-33-5
Molecular Formula:C₂₄H₃₈N₂O₆
Molecular Weight:450.576
Hs Code.:

Synonyms:methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

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Chemical Property of methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

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Technology Process of methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

There total 5 articles about methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-bromo-1,2-bis(cyanomethyl)benzene

: 1609574-33-5
methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 39 h / 110 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1338980

Reference yield:

: 171011-37-3
4-bromo-2-(hydroxymethyl)benzyl alcohol

: 1609574-33-5
methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus tribromide / diethyl ether / 7 h / 0 °C / Reflux

2: ethanol; water / 0.5 h / 0 °C / Inert atmosphere; Reflux

3: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C

4: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 39 h / 110 °C / Inert atmosphere

5: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; phosphorus tribromide; triethylamine; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1338980

Reference yield:

: 86-90-8
4-bromophthalic anhydride

: 1609574-33-5
methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene / 1.5 h / 20 °C / 760.05 Torr / Cooling with ice

1.2: 1 h / 0 - 20 °C

2.1: phosphorus tribromide / diethyl ether / 7 h / 0 °C / Reflux

3.1: ethanol; water / 0.5 h / 0 °C / Inert atmosphere; Reflux

4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 6 h / 0 - 20 °C

5.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 39 h / 110 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; hydrogen; phosphorus tribromide; diisobutylaluminium hydride; triethylamine; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0033-1338980