2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

Base Information

Chemical Name:2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide
CAS No.:908116-30-3
Molecular Formula:C₂₃H₃₀N₄O₃
Molecular Weight:410.516
Hs Code.:

Synonyms:2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

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Chemical Property of 2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

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Technology Process of 2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

There total 5 articles about 2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 917003-26-0
C₂₃H₂₈N₄O₂

: 908116-30-3
2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

Guidance literature:: With dihydrogen peroxide; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.01.098

Reference yield:

: 917003-39-5
4-Fluoro-2-(4-hydroxy-cyclohexylamino)-benzonitrile

: 908116-30-3
2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / 3 h / 90 °C

2: acetic acid / ethanol / 60 °C

3: dihydrogen peroxide; potassium hydroxide / ethanol; dimethyl sulfoxide

With dihydrogen peroxide; acetic acid; potassium hydroxide; hydrazine; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.01.098

Reference yield:

: 1292848-43-1
4-hydrazino-2-(4-hydroxy-cyclohexylamino)-benzonitrile

: 908116-30-3
2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(3 ,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / 60 °C

2: dihydrogen peroxide; potassium hydroxide / ethanol; dimethyl sulfoxide

With dihydrogen peroxide; acetic acid; potassium hydroxide; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.01.098