1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone

Base Information

• Chemical Name: 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone
• CAS No.: 1184803-52-8
• Molecular Formula: C₁₇H₁₁F₃N₂O₂
• Molecular Weight: 332.282
• Mol file: 1184803-52-8.mol

Synonyms:1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone

Chemical Property of 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone

There total 5 articles about 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trifluoroacetyl)chromone (1257345-80-4) + 1,2-diamino-benzene (95-54-5) → 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone (1184803-52-8) + (Z)-1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2(1H)-ylidene)ethanone

Guidance literature:

With acetic acid; for 4h; Overall yield = 83 %; Reflux;

DOI:10.1016/j.tet.2015.02.010

Reference yield:

2-(trifluoroacetyl)chromone (1257345-80-4) + 1,2-diamino-benzene (95-54-5) → 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone (1184803-52-8)

Guidance literature:

With acetic acid; In methanol;

DOI:10.1039/c5ra27032d

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2-yl)ethanone (1184803-52-8) + (Z)-1-(2-hydroxyphenyl)-2-(3-trifluoromethylquinoxalin-2(1H)-ylidene)ethanone

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydride / tetrahydrofuran / 6 h / Reflux

2: silica gel; sulfuric acid / 1 h / 125 - 130 °C

3: acetic acid / 4 h / Reflux

With sulfuric acid; silica gel; lithium hydride; acetic acid; In tetrahydrofuran; 1: |Claisen Condensation;

DOI:10.1016/j.tet.2015.02.010

upstream raw materials:

2-(trifluoroacetyl)chromone

1,2-diamino-benzene

2-(1,2,2,2-tetrafluoro-1-methoxyethyl)chromone

o-hydroxyacetophenone