2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Name:2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610371-40-8
Molecular Formula:C₃₁H₂₈FN₅O
Molecular Weight:505.595
Hs Code.:

Synonyms:2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Technology Process of 2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 6 articles about 2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

: 1610371-37-3
2-(4-methyl-3-(pyrimidin-2-yl)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610370-16-5
4′-(bromomethyl)-2-fluoro-5-methoxy-3′-methylbiphenyl

: 1610371-40-8
2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1610371-40-8
2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 0.33 h / 130 °C / Sealed tube; Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3: triethylamine; methanesulfonyl chloride; lithium bromide / tetrahydrofuran / 1.5 h / 0 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 110 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran; water; toluene;

Reference yield:

: 1610371-38-4
2-(1-(4-bromophenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610371-40-8
2-( 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(pyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In N,N-dimethyl-formamide; toluene;