[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Name:[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:170912-73-9
Molecular Formula:C₃₁H₄₃N₅O₄
Molecular Weight:549.714
Hs Code.:

Synonyms:[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

There total 6 articles about [2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169777-64-4
6-<<3-<2-ethyl>-1H-indol-5-yl>oxy>-1-<4-(4-nitrophenyl)piperazin-1-yl>hexan-1-one

: 170912-73-9
[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 9h; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1021/jm00018a020

Reference yield:

: 19347-73-0
6-chlorohexanoyl chloride

: 170912-73-9
[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CaCO₃ / butan-2-one / Ambient temperature

2: 64 percent / Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

3: H₂ / 10percent Pd/C / methanol / 9 h / 760 Torr / Ambient temperature

With hydrogen; caesium carbonate; calcium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00018a020

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 170912-73-9
[2-(5-{6-[4-(4-Amino-phenyl)-piperazin-1-yl]-6-oxo-hexyloxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH / 1 h / Ambient temperature

2: 64 percent / Cs₂CO₃ / dimethylformamide / 24 h / 70 °C

3: H₂ / 10percent Pd/C / methanol / 9 h / 760 Torr / Ambient temperature

With sodium hydroxide; hydrogen; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00018a020