3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester
CAS No.:167832-46-4
Molecular Formula:C₃₇H₃₂O₆
Molecular Weight:572.657
Hs Code.:

Synonyms:3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

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Chemical Property of 3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

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Technology Process of 3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

There total 4 articles about 3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 167832-45-3
3,5-dibenzyloxy-4-[2-(hydroxymethyl)-1-naphthylcarbonyl]benzoic acid 1,1-dimethylethyl ester

: 167832-46-4
3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

Guidance literature:: With sodium hypochlorite; sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm020018f

Reference yield:

: 158980-56-4
2,6-bis(benzyloxy)-4-<(1,1-dimethylethoxy)carbonyl>benzoic acid

: 167832-46-4
3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

2: 51 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

3: 52 percent / n-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

4: 35 percent / KBr; aq. NaHCO₃; NaOCl / TEMPO / CH₂Cl₂ / 2 h / 0 °C

With dmap; sodium hypochlorite; n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020018f

Reference yield:

: 158980-58-6
3,5-Bis-benzyloxy-4-chlorocarbonyl-benzoic acid tert-butyl ester

: 167832-46-4
3,5-dibenzyloxy-4-(2-formyl-1-naphthylcarbonyl)benzoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2: 52 percent / n-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

3: 35 percent / KBr; aq. NaHCO₃; NaOCl / TEMPO / CH₂Cl₂ / 2 h / 0 °C

With dmap; sodium hypochlorite; n-butyllithium; sodium hydrogencarbonate; triethylamine; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm020018f