tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

Base Information

Chemical Name:tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate
CAS No.:925421-79-0
Molecular Formula:C₃₂H₄₈FN₃O₆SSi
Molecular Weight:649.9
Hs Code.:

tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

Synonyms:tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

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Chemical Property of tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

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Technology Process of tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

There total 1 articles about tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925421-76-7
methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate

: 540-88-5
acetic acid tert-butyl ester

: 925421-79-0
tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

Guidance literature:: acetic acid tert-butyl ester; With lithium diisopropyl amide; In cyclohexane; at -45 ℃; for 0.166667h;

methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate; In cyclohexane; for 0.333333h;

Reference yield:

: 925421-79-0
tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate

: 910867-13-9
(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester

Guidance literature:: tert-butyl (5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-5-(tert-butyldimethylsilyloxy)-3-oxo-hept-6-enoate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 - 30 ℃; for 0.75h;

With water; sodium carbonate; In tetrahydrofuran;